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- Title
Arginine methylation of the B cell antigen receptor promotes differentiation.
- Authors
Infantino, Simona; Benz, Beate; Waldmann, Tanja; Jung, Manfred; Schneider, Robert; Reth, Michael
- Abstract
Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.
- Publication
The Journal of experimental medicine, 2010, Vol 207, Issue 4, p711
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20091303