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- Title
Chemerin reveals its chimeric nature.
- Authors
Yoshimura, Teizo; Oppenheim, Joost J
- Abstract
Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
- Publication
The Journal of experimental medicine, 2008, Vol 205, Issue 10, p2187
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20081736