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- Title
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components.
- Authors
Strowig, Till; Gurer, Cagan; Ploss, Alexander; Liu, Yi-Fang; Arrey, Frida; Sashihara, Junji; Koo, Gloria; Rice, Charles M; Young, James W; Chadburn, Amy; Cohen, Jeffrey I; Münz, Christian
- Abstract
Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV). These cytotoxic and interferon-gamma-producing T cell responses were human leukocyte antigen (HLA) restricted and specific for EBV-derived peptides. In HLA-A2 transgenic animals and similar to human EBV carriers, T cell responses against lytic EBV antigens dominated over recognition of latent EBV antigens. T cell depletion resulted in elevated viral loads and emergence of EBV-associated lymphoproliferative disease. Both loss of CD4(+) and CD8(+) T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell-mediated immune control that resists oncogenic transformation.
- Publication
The Journal of experimental medicine, 2009, Vol 206, Issue 6, p1423
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20081720