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- Title
Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine.
- Authors
Zaph, Colby; Du, Yurong; Saenz, Steven A; Nair, Meera G; Perrigoue, Jacqueline G; Taylor, Betsy C; Troy, Amy E; Kobuley, Dmytro E; Kastelein, Robert A; Cua, Daniel J; Yu, Yimin; Artis, David
- Abstract
Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17-producing CD4(+) T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of Th17 cells in the large intestine is significantly elevated in the absence of commensal bacteria. Commensal-dependent expression of the IL-17 family member IL-25 (IL-17E) by intestinal epithelial cells limits the expansion of Th17 cells in the intestine by inhibiting expression of macrophage-derived IL-23. We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis.
- Publication
The Journal of experimental medicine, 2008, Vol 205, Issue 10, p2191
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20080720