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- Title
T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells.
- Authors
Scheeren, Ferenc A; Nagasawa, Maho; Weijer, Kees; Cupedo, Tom; Kirberg, Jörg; Legrand, Nicolas; Spits, Hergen
- Abstract
IgM(+)IgD(+)CD27(+) B cells from peripheral blood have been described as circulating marginal zone B cells. It is still unknown when and where these cells develop. These IgM(+)IgD(+)CD27(+) B cells exhibit somatic hypermutations (SHMs) in their B cell receptors, but the exact nature of the signals leading to induction of these SHMs remains elusive. Here, we show that IgM(+)IgD(+)CD27(+) B cells carrying SHMs are observed during human fetal development. To examine the role of T cells in human IgM(+)IgD(+)CD27(+) B cell development we used an in vivo model in which Rag2(-/-)gamma(C)(-/-) mice were repopulated with human hematopoietic stem cells. Using Rag2(-/-)gamma(C)(-/-) mice on a Nude background, we demonstrated that development and induction of SHMs of human IgM(+)IgD(+)CD27(+) B cells can occur in a T cell-independent manner.
- Publication
The Journal of experimental medicine, 2008, Vol 205, Issue 9, p2033
- ISSN
1540-9538
- Publication type
Journal Article
- DOI
10.1084/jem.20070447