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- Title
Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.
- Authors
Ling, Yun M; Shaw, Michael H; Ayala, Carol; Coppens, Isabelle; Taylor, Gregory A; Ferguson, David J P; Yap, George S
- Abstract
Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo. Pathogen elimination was dependent on the interferon gamma inducible-p47 GTPase, IGTP, required PI3K activity, and was preceded by PV membrane indentation, vesiculation, disruption, and, surprisingly, stripping of the parasite plasma membrane. Denuded parasites were enveloped in autophagosome-like vacuoles, which ultimately fused with lysosomes. These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination.
- Publication
The Journal of experimental medicine, 2006, Vol 203, Issue 9, p2063
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20061318