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- Title
BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanism.
- Authors
Patke, Alina; Mecklenbräuker, Ingrid; Erdjument-Bromage, Hediye; Tempst, Paul; Tarakhovsky, Alexander
- Abstract
B cell life depends critically on the cytokine B cell-activating factor of the tumor necrosis factor family (BAFF). Lack of BAFF signaling leads to B cell death and immunodeficiency. Excessive BAFF signaling promotes lupus-like autoimmunity. Despite the great importance of BAFF to B cell biology, its signaling mechanism is not well characterized. We show that BAFF initiates signaling and transcriptional programs, which support B cell survival, metabolic fitness, and readiness for antigen-induced proliferation. We further identify a BAFF-specific protein kinase C beta-Akt signaling axis, which provides a connection between BAFF and generic growth factor-induced cellular responses.
- Publication
The Journal of experimental medicine, 2006, Vol 203, Issue 11, p2551
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20060990