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- Title
Essential role of IPS-1 in innate immune responses against RNA viruses.
- Authors
Kumar, Himanshu; Kawai, Taro; Kato, Hiroki; Sato, Shintaro; Takahashi, Ken; Coban, Cevayir; Yamamoto, Masahiro; Uematsu, Satoshi; Ishii, Ken J; Takeuchi, Osamu; Akira, Shizuo
- Abstract
IFN-beta promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA viruses. Here we show the critical role of IPS-1 in antiviral responses in vivo. IPS-1-deficient mice showed severe defects in both RIG-I- and Mda5-mediated induction of type I interferon and inflammatory cytokines and were susceptible to RNA virus infection. RNA virus-induced interferon regulatory factor-3 and nuclear factor kappaB activation was also impaired in IPS-1-deficient cells. IPS-1, however, was not essential for the responses to either DNA virus or double-stranded B-DNA. Thus, IPS-1 is the sole adapter in both RIG-I and Mda5 signaling that mediates effective responses against a variety of RNA viruses.
- Publication
The Journal of experimental medicine, 2006, Vol 203, Issue 7, p1795
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20060792