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- Title
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
- Authors
Nathan, Carl; Calingasan, Noel; Nezezon, Jon; Ding, Aihao; Lucia, M Scott; La Perle, Krista; Fuortes, Michele; Lin, Michael; Ehrt, Sabine; Kwon, Nyoun Soo; Chen, Junyu; Vodovotz, Yoram; Kipiani, Khatuna; Beal, M Flint
- Abstract
Brains from subjects who have Alzheimer's disease (AD) express inducible nitric oxide synthase (iNOS). We tested the hypothesis that iNOS contributes to AD pathogenesis. Immunoreactive iNOS was detected in brains of mice with AD-like disease resulting from transgenic expression of mutant human beta-amyloid precursor protein (hAPP) and presenilin-1 (hPS1). We bred hAPP-, hPS1-double transgenic mice to be iNOS(+/+) or iNOS(-/-), and compared them with a congenic WT strain. Deficiency of iNOS substantially protected the AD-like mice from premature mortality, cerebral plaque formation, increased beta-amyloid levels, protein tyrosine nitration, astrocytosis, and microgliosis. Thus, iNOS seems to be a major instigator of beta-amyloid deposition and disease progression. Inhibition of iNOS may be a therapeutic option in AD.
- Publication
The Journal of experimental medicine, 2005, Vol 202, Issue 9, p1163
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20051529