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- Title
Blocking IL-1 in systemic inflammation.
- Authors
Dinarello, Charles A
- Abstract
A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1beta might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
- Publication
The Journal of experimental medicine, 2005, Vol 201, Issue 9, p1355
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20050640