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- Title
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.
- Authors
Lennon, Vanda A; Kryzer, Thomas J; Pittock, Sean J; Verkman, A S; Hinson, Shannon R
- Abstract
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.
- Publication
The Journal of experimental medicine, 2005, Vol 202, Issue 4, p473
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20050304