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- Title
Decay-accelerating factor modulates induction of T cell immunity.
- Authors
Heeger, Peter S; Lalli, Peter N; Lin, Feng; Valujskikh, Anna; Liu, Jinbo; Muqim, Nasima; Xu, Yuanyuan; Medof, M Edward
- Abstract
Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells and thereby prevents complement activation on their surfaces. We demonstrate that during primary T cell activation, the absence of Daf on antigen-presenting cells (APCs) and on T cells enhances T cell proliferation and augments the induced frequency of effector cells. The effect is factor D- and, at least in part, C5-dependent, indicating that local alternative pathway activation is essential. We show that cognate T cell-APC interactions are accompanied by rapid production of alternative pathway components and down-regulation of Daf expression. The findings argue that local alternative pathway activation and surface Daf protein function respectively as a costimulator and a negative modulator of T cell immunity and explain previously reported observations linking complement to T cell function. The results could have broad therapeutic implications for disorders in which T cell immunity is important.
- Publication
The Journal of experimental medicine, 2005, Vol 201, Issue 10, p1523
- ISSN
0022-1007
- Publication type
Journal Article
- DOI
10.1084/jem.20041967