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- Title
Epigenetic centromere specification directs aurora B accumulation but is insufficient to efficiently correct mitotic errors.
- Authors
Bassett, Emily A; Wood, Stacey; Salimian, Kevan J; Ajith, Sandya; Foltz, Daniel R; Black, Ben E
- Abstract
The nearly ubiquitous presence of repetitive centromere DNA sequences across eukaryotic species is in paradoxical contrast to their apparent functional dispensability. Centromeric chromatin is spatially delineated into the kinetochore-forming array of centromere protein A (CENP-A)-containing nucleosomes and the inner centromeric heterochromatin that lacks CENP-A but recruits the aurora B kinase that is necessary for correcting erroneous attachments to the mitotic spindle. We found that the self-perpetuating network of CENPs at the foundation of the kinetochore is intact at a human neocentromere lacking repetitive alpha-satellite DNA. However, aurora B is inappropriately silenced as a consequence of the altered geometry of the neocentromere, thereby compromising the error correction mechanism. This suggests a model wherein the neocentromere represents a primordial inheritance locus that requires subsequent generation of a robust inner centromere compartment to enhance fidelity of chromosome transmission.
- Publication
The Journal of cell biology, 2010, Vol 190, Issue 2, p177
- ISSN
1540-8140
- Publication type
Journal Article
- DOI
10.1083/jcb.201001035