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- Title
Drosophila Kelch functions with Cullin-3 to organize the ring canal actin cytoskeleton.
- Authors
Hudson, Andrew M; Cooley, Lynn
- Abstract
Drosophila melanogaster Kelch (KEL) is the founding member of a diverse protein family defined by a repeated sequence motif known as the KEL repeat (KREP). Several KREP proteins, including Drosophila KEL, bind filamentous actin (F-actin) and contribute to its organization. Recently, a subset of KREP proteins has been shown to function as substrate adaptor proteins for cullin-RING (really interesting new gene) ubiquitin E3 ligases. In this study, we demonstrate that association of Drosophila KEL with Cullin-3, likely in a cullin-RING ligase, is essential for the growth of Drosophila female germline ring canals. These results suggest a role for protein ubiquitylation in the remodeling of a complex F-actin cytoskeletal structure.
- Publication
The Journal of cell biology, 2010, Vol 188, Issue 1, p29
- ISSN
1540-8140
- Publication type
Journal Article
- DOI
10.1083/jcb.200909017