We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Epigenetics, Wnt signaling, and stem cells: the Pygo2 connection.
- Authors
Horsley, Valerie
- Abstract
Stem cells use both transcriptional and epigenetic mechanisms to control gene expression and regulate tissue development and homeostasis. In this issue, Gu et al. (Gu, B., P. Sun, Y. Yuan, R.C. Moraes, A. Li, A. Teng, A. Agrawal, C. Rhéaume, V. Bilanchone, J.M. Veltmaat, et al. 2009. J. Cell Biol. 185:811-826) reveal an important link between these two mechanisms in mammary epithelial stem cells by showing that transcriptional activation of beta-catenin downstream of Wnt signaling can be regulated epigenetically through a chromatin remodeling factor, Pygo2.
- Publication
The Journal of cell biology, 2009, Vol 185, Issue 5, p761
- ISSN
1540-8140
- Publication type
Journal Article
- DOI
10.1083/jcb.200904125