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- Title
Role of A-type lamins in signaling, transcription, and chromatin organization.
- Authors
Andrés, Vicente; González, José M
- Abstract
A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human diseases termed laminopathies, including progeroid syndromes and disorders that primarily affect striated muscle, adipose, bone, and neuronal tissues. In this review, we discuss recent research supporting the concept that lamin A/C and associated nuclear envelope proteins regulate gene expression in health and disease through interplay with signal transduction pathways, transcription factors, and chromatin-associated proteins.
- Publication
The Journal of cell biology, 2009, Vol 187, Issue 7, p945
- ISSN
1540-8140
- Publication type
Journal Article
- DOI
10.1083/jcb.200904124