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- Title
New consensus nomenclature for mammalian keratins.
- Authors
Schweizer, Jürgen; Bowden, Paul E; Coulombe, Pierre A; Langbein, Lutz; Lane, E Birgitte; Magin, Thomas M; Maltais, Lois; Omary, M Bishr; Parry, David A D; Rogers, Michael A; Wright, Mathew W
- Abstract
Keratins are intermediate filament-forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.
- Publication
The Journal of cell biology, 2006, Vol 174, Issue 2, p169
- ISSN
0021-9525
- Publication type
Journal Article
- DOI
10.1083/jcb.200603161