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- Title
Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3.
- Authors
Fujito, Tsutomu; Ikeda, Wataru; Kakunaga, Shigeki; Minami, Yukiko; Kajita, Mihoko; Sakamoto, Yasuhisa; Monden, Morito; Takai, Yoshimi
- Abstract
Immunoglobulin-like Necl-5/Tage4/poliovirus receptor (PVR)/CD155, originally identified as the PVR, has been shown to be up-regulated in cancer cells and to enhance growth factor-induced cell movement and proliferation. In addition, Necl-5 heterophilically trans-interacts with nectin-3, a cell-cell adhesion molecule known to form adherens junctions in cooperation with cadherin. We show here that Necl-5 was down-regulated from cell surface upon cell-cell contacts in NIH3T3 cells. This down-regulation of Necl-5 was initiated by its interaction with nectin-3 and was mainly mediated by clathrin-dependent endocytosis. Then, the down-regulation of Necl-5 induced in this way reduced movement and proliferation of NIH3T3 cells. These results indicate that the down-regulation of Necl-5 induced by its interaction with nectin-3 upon cell-cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation.
- Publication
The Journal of cell biology, 2005, Vol 171, Issue 1, p165
- ISSN
0021-9525
- Publication type
Journal Article
- DOI
10.1083/jcb.200501090