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- Title
The next generation of liposome delivery systems: recent experience with tumor-targeted, sterically-stabilized immunoliposomes and active-loading gradients.
- Authors
Abra, R M; Bankert, R B; Chen, F; Egilmez, N K; Huang, K; Saville, R; Slater, J L; Sugano, M; Yokota, S J
- Abstract
Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-beta1 integrin Fab' ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.
- Publication
Journal of liposome research, 2002, Vol 12, Issue 1-2, p1
- ISSN
0898-2104
- Publication type
Journal Article
- DOI
10.1081/lpr-120004770