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- Title
Antigenicity of poly(I) and ROS-poly(I) and their recognition of human anti-DNA autoantibodies.
- Authors
Tasneem, S; Ali, R
- Abstract
The effect of hydroxyl radicals on polyinosinic acid [poly(I)] was studied. Strand breaks, base alteration and a decrease in absorbance at 248 nm (lambda max) were observed upon *OH modification of poly(I). The broad antigen specificity of the induced anti-poly(I) and anti-ROS-poly(I) antibodies showed diverse antigen binding characteristics similar to those of SLE autoantibodies. Recognition of both poly(I) and ROS-poly(I) by human SLE anti-DNA autoantibodies was observed. The possible significance of these findings in the etiology of SLE has been discussed.
- Publication
Immunological investigations, 2001, Vol 30, Issue 4, p335
- ISSN
0882-0139
- Publication type
Journal Article
- DOI
10.1081/imm-100108167