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- Title
Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases.
- Authors
Bock, K W; Gschaidmeier, H; Heel, H; Lehmköster, T; Münzel, P A; Bock-Hennig, B S
- Abstract
Functions and regulation of selected human UDP-glucuronosyltransferases (UGT1A1, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B15) are summarized. Evidence for at least two PAH-inducible UGTs (UGT1A6 and UGT1A9) is presented, which, however, are also constitutively expressed in a tissue- and cell-specific manner. These isoforms have recently been characterized to conjugate planar and bulky phenols, respectively. Using a selective RT-PCR method, UGT1A6 expression was detected in a variety of tissues (liver, kidney, lung, intestine, and pharyngeal mucosa). PAH-inducible UGTs may cooperate in the metabolism of phenolic metabolites of benzo(a)pyrene. Studies with stably expressed isoforms suggest that UGT1A9 is responsible for the formation of benzo(a)pyrene-3.6-diphenol diglucuronide, the major biliary metabolite of benzo(a)pyrene.
- Publication
Drug metabolism reviews, 1999, Vol 31, Issue 2, p411
- ISSN
0360-2532
- Publication type
Journal Article
- DOI
10.1081/dmr-100101927