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- Title
Acute poisoning with emamectin benzoate.
- Authors
Yen, Tzung-Hai; Lin, Ja-Liang
- Abstract
Emamectin benzoate is the 4'-deoxy-4'-epi-methyl-amino benzoate salt of avermectin B1 (abamectin), which is similar structurally to natural fermentation products of Streptomyces avermitilis. Emamectin benzoate is being developed as a newer broad-spectrum insecticide for vegetables and has a very low application rate. The mechanism of action involves stimulation of high-affinity GABA receptors and a consequent increase in membrane chloride ion permeability. Animal studies indicate a wide margin of safety because mammalian species are much less sensitive due to lower GABA receptor affinities and relative impermeability of the blood-brain barrier. Notably, the literature has not reported human exposure resulting in toxicity.
- Publication
Journal of toxicology. Clinical toxicology, 2004, Vol 42, Issue 5, p657
- ISSN
0731-3810
- Publication type
Journal Article
- DOI
10.1081/clt-200026968