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- Title
Dimercaptosuccinic acid and Prussian Blue in the treatment of acute thallium poisoning in rats.
- Authors
Rusyniak, Daniel E; Kao, Louise W; Nanagas, Kristine A; Kirk, Mark A; Furbee, R Brent; Brizendine, Edward J; Wilmot, Paul E
- Abstract
Despite being banned as a pesticide, thallium still results in human and animal poisonings. Current recommended treatments include the use of the chemical Prussian Blue. Limitations in its availability may result in Prussian Blue not being obtainable in the thallium-poisoned patient. The chelator 2,3-Dimercaptosuccinic acid (DMSA) is currently FDA-approved for use in childhood lead poisoning and has been reported to be beneficial in treating other heavy metal poisonings. The objective of this study was to determine the efficacy of DMSA as a treatment for thallium poisoning by studying mortality and whole-brain concentrations in thallium poisoned rats.
- Publication
Journal of toxicology. Clinical toxicology, 2003, Vol 41, Issue 2, p137
- ISSN
0731-3810
- Publication type
Journal Article
- DOI
10.1081/clt-120019129