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- Title
Effect of diaspirin crosslinked hemoglobin (DCLHb HemAssist) during high blood loss surgery on selected indices of organ function.
- Authors
Schubert, Armin; O'Hara, Jerome F, Jr; Przybelski, Robert J; Tetzlaff, John E; Marks, Kenneth E; Mascha, Edward; Novick, Andrew C
- Abstract
The safety of the hemoglobin based oxygen carrier diaspirin crosslinked hemoglobin (DCLHb) has been reported only in the low (50-200 mg/kg) dose range [Przybelski. R.J.; Daily, E.K.; Kisicki, J.C.; Mattia-Goldberg, C.; Bounds, M.J.; Colburn, W.A. Phase I study of the safety and pharmacologic effects of diaspirin crosslinked hemoglobin solution. Crit. Care Med. 1996, 24 (12), 1993-2000, Bloomfield, E.; Rady, M.; Popovich, M.; Esfandiari, S.; Bedocs, N. The use of diaspirin crosslinked hemoglobin (DCLHb 1996, 95, (3A), A220.]. We conducted a randomized prospective open-label trial of DCLHb and packed red blood cells (PRBCs) in high-blood loss surgical patients to show the effect of 750 ml DCLHb (approximately 1000 mg/kg) on selected indices of organ function.
- Publication
Artificial cells, blood substitutes, and immobilization biotechnology, 2002, Vol 30, Issue 4, p259
- ISSN
1073-1199
- Publication type
Journal Article
- DOI
10.1081/bio-120006118