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- Title
Human cytidine deaminase: understanding the catalytic mechanism.
- Authors
Costanzi, S; Vincenzetti, S; Vita, A; Lambertucci, C; Taffi, S; Volpini, R; Vittori, S; Cristalli, G
- Abstract
In the absence of an experimentally elucidated three-dimensional structure of the human CDA, we built an homology model of this enzyme starting from the crystal structure of its E. coli homologous. Furthermore, we docked in the active site alternatively the substrate, the intermediate or the product. By means of molecular dynamics simulations, we determined the topology of the active site, identifying the amino acids involved in the catalytic mechanism, and outlining the central role played by E67.
- Publication
Nucleosides, nucleotides & nucleic acids, 2003, Vol 22, Issue 5-8, p1539
- ISSN
1525-7770
- Publication type
Journal Article
- DOI
10.1081/NCN-120023029