Title

Bioactive sesquiterpenes from an endophytic fungus Bipolaris sorokiniana isolated from a popular medicinal plant Costus speciosus.

Authors

Qader, M. Mallique; Kumar, N. Savitri; Jayasinghe, Lalith; Araya, Hiroshi; Fujimoto, Yoshinori

Abstract

Bipolaris sorokiniana, a fungal endophyte, was isolated from the leaves ofCostus speciosus, a popular medicinal plant used to control diabetes. Fermentation of the fungus in potato dextrose broth and chromatographic purification of the ethyl acetate (EtOAc) extracts of the culture broth and mycelium yielded two rare sesquiterpenes helminthosporal acid (1) and helminthosporol (2), together with ergosterol. Compounds1and2showed a strong phytotoxic effect on lettuce seed germination and toxicity against brine shrimps. Compound1also showed antifungal activity. Complete assignments of1H and13C NMR data of compound1are described for the first time.

Subjects

SESQUITERPENES; COSTUS; HELMINTHOSPORIUM

Publication

Mycology: An International Journal on Fungal Biology, 2017, Vol 8, Issue 1, p17

ISSN

2150-1203

Publication type

Academic Journal

DOI

10.1080/21501203.2016.1269844