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- Title
L1 elements, processed pseudogenes and retrogenes in mammalian genomes.
- Authors
Wenyong Ding; Lin Lin; Bing Chen; Jianwu Dai
- Abstract
Long interspersed nuclear elements 1 (L1 elements or LINE1) are the most active autonomous retrotransposons in mammalian genomes. In addition to L1 elements themselves, other protein-coding mRNAs can also be reverse transcribed and integrated into the genome through the L1-mediated retrotransposition, leading to the formation of processed pseudogenes (PPs) and retrogenes, both of which are characterized by the lack of introns and the presence of a 3' polyA tract and flanking direct repeats. PPs are unable to encode a functional protein and have accumulated frameshift mutations and premature stop codons during evolution. A few of PPs are transcriptionally active. Retrogenes preserve undisrupted coding frames and are capable of encoding a functional protein that is identical or nearly identical to that of the progenitor gene. There is a significant excess of retrogenes that originate from the X chromosome and are retrotransposed into autosomes, and most of these retrogenes are specially expressed in male germ cells, suggesting the inactivation of X-linked genes during male meiosis provides a strong selection pressure on retrogenes originating from the X chromosome. iubmb Life, 58: 677-685, 2006
- Publication
IUBMB Life, 2006, Vol 58, Issue 12, p677
- ISSN
1521-6543
- Publication type
Academic Journal
- DOI
10.1080/15216540601034856