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- Title
Transient up-regulation of liver mitochondrial thymidine kinase activity in proliferating mitochondria.
- Authors
Elholm, M; Hollås, H; Issalene, C; Barroso, J F; Berge, R K; Flatmark, T
- Abstract
Administration of the fatty acid analogue tetradecylthioacetic acid (TTA) to rodents up-regulates peroxisomal and mitochondrial lipid-metabolizing enzymes and induces a proliferation of these organelles in hepatocytes. We show here that male NMRI mice fed a diet containing 0.3% (w/w) TTA revealed a transient two-fold increase in the incorporation of [3H]thymidine into the liver mtDNA followed by a 1.6-fold increase in the content of mtDNA. In addition, a transient three-fold increase in the mitochondrial thymidine kinase (TK2) activity and a slight increase in the DNA polymerase gamma activity was observed, indicating that the TTA induced mitochondrial proliferation is linked to an up-regulation of the mitochondrial thymidine kinase activity.
- Publication
IUBMB life, 2001, Vol 51, Issue 2, p99
- ISSN
1521-6543
- Publication type
Journal Article
- DOI
10.1080/15216540119294