Title

Preussiate, a new urease inhibitory chalcone from Dioscorea preussii Pax.

Authors

Ali, Muhammad Shaiq; Iqbal, Seerat; Lateef, Mehreen; Joseph, Ngoupayo

Abstract

The phytochemical investigation of the aqueous methanolic extract of the aerial parts of Dioscorea preussii, led to the isolation of a new chalcone preussiate (1) along with 10 other compounds including xanthomicrol (2), cholestan-3-one (3), arjunolic acid (4), tormentic acid (5), ursolic acid (6), betulin (7), lupeol (8), p-hydroxybenzoic acid (9), isovanillin (10) and vanillic acid (11), being reported for the first time from this plant. Their structures were established by spectroscopic techniques including 2D NMR spectroscopy. All the isolates were subjected to the biological screening but only showed antioxidant and urease inhibitory properties. The compounds 1,8 and 11 displayed the most potent urease inhibitory properties with IC50 values, 22.4, 33.3 and 35.7 µM, respectively, while 3 was moderately active. The compound 11 showed potent antioxidant activity among all the tested isolates with an IC50 value of 45.3 µM.

Subjects

URSOLIC acid; NUCLEAR magnetic resonance spectroscopy; CHALCONE; YAMS; UREASE

Publication

Natural Product Research, 2025, Vol 39, Issue 1, p1

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2023.2248350