Title

The role of active metabolites isolated from Jasminum multiflorum flowers against hepatitis C virus infection and related hepatocellular carcinoma.

Authors

El-Hawary, Seham S.; EL-Hefnawy, Hala M.; Elemeery, Moustafa N.; Osman, Samir M.; EL-Raey, Mohamed A.; Mokhtar, Fatma Alzahraa; Pan, Cheol H.; Ibrahim, Haitham Ali

Abstract

Jasminum multiflorum Burm. f. (J. multiflorum) is an ornamental plant with traditional medicinal importance. This study aims to evaluate the activity of J. multiflorum isolated compounds against hepatocellular carcinoma cells infected with hepatitis C virus (HCV) in vitro. The in vitro anti-viral and anti-oncogenic-related activity were validated by anchorage-independent assay plus transwell migration/invasion and spreading assay. In addition to chromatographic isolation of the active metabolites. The flower extract demonstrated a significant antiviral potential through reducing active viral replication by more than 90%. Study results credit this to specific reduction of viral NS5A and cellular EphA2 protein levels. Molecular docking analysis proved the role of the isolated compounds especially multifloroside, jasfloroside A and jasfloroside B as possible anti HCV molecules.

Subjects

HEPATITIS C; HEPATOCELLULAR carcinoma; JASMINE; HEPATITIS C virus; ORNAMENTAL plants

Publication

Natural Product Research, 2022, Vol 36, Issue 10, p2625

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2021.1913588