Title

New nor-oleanane triterpenoids from the fruits of Stauntonia brachyanthera with potential anti-inflammation activity.

Authors

Li, Jiaheng; Du, Kaicheng; Liu, Dan; Meng, Dali

Abstract

The continuing studies on the fruits of Stauntonia brachyanthera led to the isolations of 6 normal and nor-oleanane triterpenoids, including two new compounds, brachyantheoraside B10 (1) and brachyantheraside C1 (2). Compounds 1–3 showed inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 macrophages with the IC50 values of 27.04, 26.22, and 21.41 μM, respectively, which were all stronger than that of indomethacin. The study not only revealed a new type of nor-oleanane triterpenoids, but also confirmed the anti-inflammation abilities of three type nor-oleanane triterpenoids as the inhibitors of NO production.

Subjects

TRITERPENOIDS; FRUIT; NITRIC oxide

Publication

Natural Product Research, 2020, Vol 34, Issue 7, p915

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786419.2018.1540478