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- Title
Triterpenoids with neurotrophic activity from Ganoderma lucidum.
- Authors
Zhang, Xiao-Qi; Ip, Fanny C F; Zhang, Dong-Mei; Chen, Li-Xin; Zhang, Wei; Li, Yao-Lan; Ip, Nancy Y; Ye, Wen-Cai
- Abstract
A new triterpenoid, 4,4,14α-trimethyl-5α-chol-7,9(11)-dien-3-oxo-24-oic acid (1), together with seven known triterpenoids, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by extensive spectroscopic analyses. Bioassay results revealed that compounds 1 and methyl ganoderic acid B (5) had nerve growth factor-like neuronal survival-promoting effects, whereas compounds 1, and 4-7 showed brain-derived neurotrophic factor-like neuronal survival-promoting activities.
- Publication
Natural product research, 2011, Vol 25, Issue 17, p1607
- ISSN
1478-6427
- Publication type
Journal Article
- DOI
10.1080/14786419.2010.496367