Title

Hemisynthesis of new labdane derivatives from (-)-sclareol.

Authors

waheb Fekih, Abdel; Gafsi, Karima; Ferreiro-Mederos, Letitia; Hanquet, Gilles

Abstract

A straightforward and very simple access to different analogues of ( )-subersic acid 7 , the unnatural enantiomer (compounds 12 ) from naturally occurring (-)-sclareol 1 is described. We also report new conditions for the preparation of keto-intermediate 8 using maleic acid and describe hemiketal 11 as the new intermediate of degradative oxidation of 1.

Subjects

ENANTIOMERS; CHIRALITY; OXIDATION; MALEIC acid; MALEIC anhydride; NATURAL products

Publication

Natural Product Research, 2006, Vol 20, Issue 10, p887

ISSN

1478-6419

Publication type

Academic Journal

DOI

10.1080/14786410500160686