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- Title
Effect of fetal dexamethasone exposure on the development of adult insulin sensitivity in a rat model.
- Authors
O'Brien, Karen; Sekimoto, Hiroko; Boney, Charlotte; Malee, Maureen
- Abstract
A rat model was designed to determine if fetal dexamethasone exposure is associated with decreased insulin sensitivity in adulthood, manifested as decreased binding of p85 to phosphorylated insulin receptor substrate-1 (IRS-1) within the phosphatidylinositol 3-kinase (PI 3-kinase) pathway of insulin signaling. Additionally, the study investigated whether a differential effect exists in male and female rodent offspring, such that females demonstrate decreased binding of p85 to IRS-1 after exposure to dexamethasone in utero.
- Publication
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2008, Vol 21, Issue 9, p623
- ISSN
1476-4954
- Publication type
Journal Article
- DOI
10.1080/14767050802213073