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- Title
Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia.
- Authors
Chaiworapongsa, Tinnakorn; Romero, Roberto; Kim, Yeon Mee; Kim, Gi Jin; Kim, Mi Ran; Espinoza, Jimmy; Bujold, Emmanuel; Gonçalves, Luís; Gomez, Ricardo; Edwin, Samuel; Mazor, Moshe
- Abstract
Accumulating evidence suggests that the balance between vascular endothelial growth factor (VEGF), placental growth factor (PIGF), and their receptors is important for effective vasculogenesis, angiogenesis, and placental development. Recently, the soluble form of VEGFR-1 (sVEGFR-1), an antagonist to VEGF and PIGF, has been implicated in the pathophysiology of pre-eclampsia. Plasma sVEGFR-1 concentration is elevated in pre-eclampsia at the time of clinical diagnosis and correlates with the severity of the disease. The purpose of this study was to determine whether the concentrations of sVEGFR-1 in plasma of pre-eclamptic patients change prior to the clinical manifestations of the disease.
- Publication
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2005, Vol 17, Issue 1, p3
- ISSN
1476-7058
- Publication type
Journal Article
- DOI
10.1080/14767050400028816