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- Title
Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6.
- Authors
Najar, Mehdi; Rouas, Redouane; Raicevic, Gordana; Boufker, Hichame Id; Lewalle, Philippe; Meuleman, Nathalie; Bron, Dominique; Toungouz, Michel; Martiat, Philippe; Lagneaux, Laurence
- Abstract
Mesenchymal stromal cells (MSC) have been shown to possess immunomodulatory functions and proposed as a tool for managing or preventing graft-versus-host disease (GvHD) as well as promoting clinical transplantation tolerance. We investigated the capacity of human bone marrow (BM) MSC to modulate the proliferation of T cells obtained from peripheral blood (PB) and umbilical cord blood (CB). We addressed the importance of the MSC:T-cell ratio, requirement for cell contact and impact of soluble factors on the MSC-mediated effects. We also analyzed whether regulatory T cells could be modulated by MSC in co-cultures.
- Publication
Cytotherapy, 2009, Vol 11, Issue 5, p570
- ISSN
1477-2566
- Publication type
Journal Article
- DOI
10.1080/14653240903079377