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- Title
Isolation of early hematopoietic cells, including megakaryocyte progenitors, in the ALDH-bright cell population of cryopreserved, banked UC blood.
- Authors
Gentry, T; Deibert, E; Foster, S J; Haley, R; Kurtzberg, J; Balber, A E
- Abstract
ALDH-bright (ALDH(br)) cell populations sorted from freshly collected umbilical cord blood (UCB) on the basis of their high aldehyde dehydrogenase (ALDH) activity are highly enriched for HPC. HPC with low ALDH activity (ALDH(dim)) are primarily short-term progenitors, whereas progenitors that initiate long-term cultures or establish long-term grafts in xenograft models are ALDH(br). We examined the multilineage hematopoietic and platelet progenitor activities of ALDH(br) cells recovered from cryopreserved UCB units typically employed in the practice of clinical transplantation.
- Publication
Cytotherapy, 2007, Vol 9, Issue 6, p569
- ISSN
1465-3249
- Publication type
Journal Article
- DOI
10.1080/14653240701466347