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- Title
Process validation and clinical evaluation of a protocol to generate gene-modified T lymphocytes for imunogene therapy for metastatic renal cell carcinoma: GMP-controlled transduction and expansion of patient's T lymphocytes using a carboxy anhydrase IX-specific scFv transgene.
- Authors
Lamers, C H J; van Elzakker, P; Langeveld, S C L; Sleijfer, S; Gratama, J W
- Abstract
Adoptive transfer of autologous T cells that are gene-transduced to express Ag-specific receptors represents an experimental strategy to provide tumor-specific immunity to cancer patients. We studied this concept in patients with metastatic renal cell cancer (RCC) using retroviral transduction of T cells with a single-chain Ab-G250 chimeric receptor [scFv(G250)]. We describe the validation of our clinical protocol for gene transduction and expansion of human T lymphocytes.
- Publication
Cytotherapy, 2006, Vol 8, Issue 6, p542
- ISSN
1465-3249
- Publication type
Journal Article
- DOI
10.1080/14653240601056396