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- Title
Umbilical cord blood-derived cells for tissue repair.
- Authors
Körbling, M; Robinson, S; Estrov, Z; Champlin, R; Shpall, E
- Abstract
Hematopoietic tissue-derived cells, including stem cells, have been shown to generate solid organ tissue-specific cells. Besides bone marrow and peripheral blood, umbilical cord blood (UCB) has the advantage of being an easily accessible stem cell source provided as a banked cell product. Using the xenogeneic human into NOD/SCID mouse stem cell transplant model preliminary data suggest UCB-derived tissue-specific cells generated in liver, pancreas, CNS and endothelium. In a clinical sex-mismatched UCB transplant setting Y-positive, UCB-derived gastrointestinal epithelial cells and CNS-specific cells have been identified in female patients. The potential therapeutic use of UCB cells for tissue repair is, however, limited by a low total stem cell number available and by HLA-disparity.
- Publication
Cytotherapy, 2005, Vol 7, Issue 3, p258
- ISSN
1465-3249
- Publication type
Journal Article
- DOI
10.1080/14653240510027145