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Title
Low oxygen tension enhances the stimulation and proliferation of human T lymphocytes in the presence of IL-2.
Authors
Carswell, K S; Weiss, J W; Papoutsakis, E T
Abstract
Optimization of the culture environment for the ex vivo expansion of T cells is crucial for obtaining the large doses of cells needed for cellular immunotherapy. O2 tension is a key parameter that impacts the proliferation and quality of the expanded T cells.