We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Biomarkers to assess the utility of potential reduced exposure tobacco products.
- Authors
Hatsukami, Dorothy K; Benowitz, Neal L; Rennard, Stephen I; Oncken, Cheryl; Hecht, Stephen S
- Abstract
To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular disease, and fetal toxicity. The goal of these workgroups was to identify biomarkers that offer some promise as measures of exposure or toxicity and ultimately may serve as indicators for future disease risk. Recommendations were based on the relationship of the biomarker to what is known about mechanisms of tobacco-related pathogenesis, the extent to which the biomarker differs among smokers and nonsmokers, and the sensitivity of the biomarker to changes in smoking status. Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area.
- Publication
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006, Vol 8, Issue 2, p169
- ISSN
1462-2203
- Publication type
Journal Article
- DOI
10.1080/14622200600576628