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- Title
APOE epsilon4 allele carriers: Biological, psychological, and social variables associated with cognitive impairment.
- Authors
Sachs-Ericsson, Natalie J; Sawyer, Kathryn A; Corsentino, Elizabeth A; Collins, Nicole A; Blazer, Dan G
- Abstract
The apolipoprotein (APOE) epsilon4 allele genotype is a risk factor for dementia, but not all people with the APOE epsilon4 allele develop cognitive impairment (CI). Among participants with the APOE epsilon4 allele (N = 664), we identified biological, psychological, and social variables that discriminate between participants who develop CI from those who do not. We then determined if these variables predicted CI in noncarriers (N = 1421). In the sample as a whole we then determined if each of these identified variables moderate the relationship between the APOE epsilon4 allele and CI.
- Publication
Aging & mental health, 2010, Vol 14, Issue 6, p679
- ISSN
1364-6915
- Publication type
Journal Article
- DOI
10.1080/13607860903292594