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- Title
Valproic acid does not affect markers of human immunodeficiency virus disease progression.
- Authors
Ances, Beau M; Letendre, Scott; Buzzell, Maria; Marquie-Beck, Jennifer; Lazaretto, Deborah; Marcotte, Thomas D; Grant, Igor; Ellis, Ronald J; HNRC Group
- Abstract
Valproic acid (VPA) reduces latent human immunodeficiency virus (HIV) reservoirs by activating resting CD4+ cells. This retrospective case-control study (n = 30) examined effects of VPA on markers of HIV progression. VPA was not associated with changes in cerebrospinal fluid viral loads (VL), plasma VL, or neuropsychological performance. VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention.
- Publication
Journal of neurovirology, 2006, Vol 12, Issue 5, p403
- ISSN
1355-0284
- Publication type
Journal Article
- DOI
10.1080/13550280600981695