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- Title
Effect of intensive lifestyle intervention on C-reactive protein in subjects with impaired glucose tolerance and obesity. Results from a randomized controlled trial with 5-year follow-up.
- Authors
Andersson, Jonas; Boman, Kurt; Jansson, Jan-Håkan; Nilsson, Torbjørn K; Lindahl, Bernt
- Abstract
C-reactive protein (CRP) is a marker of metabolic and cardiovascular disease. To study the effects of lifestyle on CRP in a high-risk population we conducted a randomized controlled trial on 200 obese subjects (BMI > 27 kg m(-2)) with impaired glucose tolerance recruited from primary care settings. They were randomized to either a 1-month stay at a wellness centre focusing on diet, exercise and stress management (intervention group) or 30-60 min of oral and written information on lifestyle intervention (control group). A significant reduction of CRP was observed after 1 month and 1 year in the intervention group. They reduced their CRP levels more than the control group 1 year after intervention (p=0.004). In conclusion lifestyle intervention can decrease CRP in obese individuals with impaired glucose tolerance for up to 1 year. Further research is needed to evaluate whether the CRP level reduction translates into a decreased risk for cardiovascular morbidity.
- Publication
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2008, Vol 13, Issue 7, p671
- ISSN
1366-5804
- Publication type
Journal Article
- DOI
10.1080/13547500802661266