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- Title
Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis.
- Authors
Akar, Harun; Seldin, David C; Magnani, Barbarajean; O'Hara, Carl; Berk, John L; Schoonmaker, Christopher; Cabral, Howard; Dember, Laura M; Sanchorawala, Vaishali; Connors, Lawreen H; Falk, Rodney H; Skinner, Martha
- Abstract
We compared a new serum immunoassay for quantitation of serum free light chains (FLC) with the conventional tests for clonal immunoglobulin production: bone marrow immunohistochemistry, serum immunofixation electrophoresis, and urine immunofixation electrophoresis. Serum samples from 169 patients with AL amyloidosis and 20 controls were examined. Elevated levels of kappa-FLC and lambda-FLC were found in 94% and 93% of patients with the respective clonal disease. However, false positive elevations of kappa-FLC and lambda-FLC were found in 30% and 44% of patients with clonal disease of the other light chain subtype. We found that the FLC level was a reliable test for the diagnosis of clonal disease when the FLC kappa:lambda ratio was abnormal and was comparable to the conventional tests in patients with AL amyloidosis. After a histologic tissue diagnosis of amyloidosis, determining the type as AL amyloidosis relies on a panel of hematologic tests to determine light chain clonality and the exclusion other forms of amyloidosis.
- Publication
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2005, Vol 12, Issue 4, p210
- ISSN
1350-6129
- Publication type
Journal Article
- DOI
10.1080/13506120500352339