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- Title
G protein-coupled receptors in and on the cell nucleus: a new signaling paradigm?
- Authors
Boivin, Benoit; Vaniotis, George; Allen, Bruce G; Hébert, Terence E
- Abstract
Signaling from internalizing and endosomal receptors has almost become a classic GPCR paradigm in the last several years. However, it has become clear in recent years that GPCRs also elicit signals when resident at other subcellular sites including the endoplasmic reticulum, Golgi apparatus, and the nucleus. In this review we discuss the nature, function, and trafficking of nuclear GPCR signaling complexes, as well as potential sources of endogenous and exogenous ligands. Finally, we pose a series of questions that will need to be answered in the coming years to confirm and extend this as a new paradigm for GPCR signaling.
- Publication
Journal of receptor and signal transduction research, 2008, Vol 28, Issue 1-2, p15
- ISSN
1079-9893
- Publication type
Journal Article
- DOI
10.1080/10799890801941889