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- Title
Males and females differ in response to opioid agonist medications.
- Authors
Jones, Hendrée E; Fitzgerald, Heather; Johnson, Rolley E
- Abstract
Few clinical trials include sex as a factor. This analysis explored within-sex differences in response to opioid agonist medications. Males and females randomly assigned to buprenorphine, LAAM, or methadone were compared on opioid use and retention in treatment. Females receiving buprenorphine had less objective drug use than females receiving methadone, while males receiving LAAM had less objective drug use than males receiving buprenorphine. Retention in treatment was longer for both sexes receiving methadone versus LAAM. Within-subject change results indicate that all three medications benefit both sexes. Clinical trials should be designed to examine the impact of sex on outcomes.
- Publication
The American journal on addictions, 2005, Vol 14, Issue 3, p223
- ISSN
1055-0496
- Publication type
Journal Article
- DOI
10.1080/10550490590949569