We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A mixture gatekeeping procedure based on the Hommel test for clinical trial applications.
- Authors
Brechenmacher, Thomas; Xu, Jane; Dmitrienko, Alex; Tamhane, Ajit C
- Abstract
When conducting clinical trials with hierarchically ordered objectives, it is essential to use multiplicity adjustment methods that control the familywise error rate in the strong sense while taking into account the logical relations among the null hypotheses. This paper proposes a gatekeeping procedure based on the Hommel (1988) test, which offers power advantages compared to other p value-based tests proposed in the literature. A general description of the procedure is given and details are presented on how it can be applied to complex clinical trial designs. Two clinical trial examples are given to illustrate the methodology developed in the paper.
- Publication
Journal of biopharmaceutical statistics, 2011, Vol 21, Issue 4, p748
- ISSN
1520-5711
- Publication type
Journal Article
- DOI
10.1080/10543406.2011.551334