We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Simultaneous presentation of acute monoblastic leukemia and mantle cell lymphoma: case report and review of the literature.
- Authors
Pawarode, A; Baer, M R; Padmanabhan, S; Wallace, P K; Barcos, M; Sait, S N J; Block, A W; Wetzler, M; Battiwalla, M
- Abstract
This paper reports a 73-year old woman with simultaneous presentation of acute monoblastic leukemia (acute myeloid leukemia (AML), French-American-British (FAB) type M5a) and mantle cell lymphoma. The patient presented with wasting, generalized lymphadenopathy, an extensive infiltrative rash and pancytopenia. Bone marrow and lymph node histopatholology showed extensive infiltration by leukemic monoblasts. Marrow cytogenetics revealed a complex karyotype, including t(8;16)(p11;p13). Flow cytometric immunophenotyping of peripheral blood, lymph node and bone marrow demonstrated two populations, expressing CD5, CD19, CD20 and CD22 and CD45, HLA-DR, CD13, CD33, CD14 and CD38, respectively. A focus of abnormal lymphocytes in the lymph node biopsy demonstrated BCL1 expression and t(11;14)(p11;p13) by fluorescence in situ hybridization and immunoglobulin heavy chain gene rearrangement by the polymerase chain reaction. The patient received infusional cytarabine, daunorubicin and etoposide chemotherapy, with complete remission of both the AML and the mantle cell leukemia. To the authors' knowledge, this is the first report of simultaneous presentations of AML, FAB M5a and mantle cell lymphoma. The case is discussed and the literature is reviewed.
- Publication
Leukemia & lymphoma, 2005, Vol 46, Issue 12, p1813
- ISSN
1042-8194
- Publication type
Journal Article
- DOI
10.1080/10428190500244258