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- Title
Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma.
- Authors
Rack, K; Delannoy, A; Ravoet, C; Vannuffel, P; Hamels, J; Gillerot, Y
- Abstract
Follicular Lymphoma is a low grade malignancy of mature B-cells. The hallmark chromosome abnormality is the translocation t(14;18) which is observed in 70 - 80% of cases with a translocation t(3;14) present in a further 10%. Rarely both of these translocations, or one of their variants, may be present. These co-incident translocations usually involve different Ig loci or different Ig alleles. We present here a case of Follicular Lymphoma with leukemic presentation and a complex translocation involving the IgH, BCL2 and BCL6 loci. Double oncogene translocations to a single immunoglobulin locus are extremely rare in lymphomas with few cases described to date. To our knowledge this is the first reported case with a complex translocation involving these loci.
- Publication
Leukemia & lymphoma, 2005, Vol 46, Issue 10, p1513
- ISSN
1042-8194
- Publication type
Journal Article
- DOI
10.1080/10428190500125648